I've been using Prevx1 for over a year now, and really like it. It's effective, easy to use, handles every kind of malware (you don't need a bunch of other antispyware and other stuff), and doesn't slow my machine down. I think it could use a few more features, but they're always improving it and take suggestions well. They've also always had great support. I consider Prevx1 the cornerstone of my defense, it's the one app I wouldn't go without.
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